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Our top choices for Northeast Missouri hotels

A bedroom with a four-poster bed, a bedside table with a lamp, a desk with a telephone, and a bathroom with a bathtub and a hanging plant.

1. Depot Inn and Suites

La Plata

Kimberly

CA $134 total

includes taxes & fees

Dec 6 - Dec 7

A hotel room with two beds, a nightstand with a lamp, and a window with blinds.

2. Super 8 by Wyndham Kirksville-University Area

Kirksville

Cori

CA $103 total

includes taxes & fees

Nov 22 - Nov 23

A reception area with a counter, a trash bin, and a seating area with chairs.

3. Travelier Motel

Macon

Jason

CA $74 total

includes taxes & fees

Nov 24 - Nov 25

A hotel room with a large bed, a separate bathroom with a bathtub, and a desk with a chair.

4. Best Western On The River

Hannibal

Rob

CA $164 total

includes taxes & fees

Nov 19 - Nov 20

A hotel room with a large bed, two bedside lamps, a nightstand with a phone, a mirror, and a bathtub.

5. Oak Hill Inn & Suites

Canton

Peter

CA $148 total

includes taxes & fees

Dec 10 - Dec 11

A modern dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and a patterned wall decoration.

6. Holiday Inn Express & Suites Kirksville - University Area by IHG

Kirksville

Jimmy

CA $183 total

includes taxes & fees

Nov 29 - Nov 30

A lobby with a reception desk, a seating area with sofas and armchairs, a large potted plant, and a door leading outside.

7. Sleep Inn & Suites Hannibal West

Hannibal

Sarah

CA $180 total

includes taxes & fees

Dec 6 - Dec 7

A bathroom with a large bathtub, a chair, and a small shelf with plants.

8. Pinemark Inn & Suites

St. Clair

Michael

CA $200 total

includes taxes & fees

Nov 15 - Nov 16

A hotel reception desk with a modern design, a sign indicating it's a Hilton Honors location, and a variety of snacks and beverages on shelves.

9. Hampton Inn By Hilton Warrenton I-70

Warrenton

Richard

CA $222 total

includes taxes & fees

Dec 10 - Dec 11

A hotel room with a desk, a blue chair, a television, a microwave, and a refrigerator.

10. Comfort Inn Sullivan

Sullivan

Wayne

CA $175 total

includes taxes & fees

Dec 1 - Dec 2

A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.

11. The Wildwood Hotel

Wildwood

Lori

CA $132 total

includes taxes & fees

Dec 8 - Dec 9

A hotel lobby with a seating area, a dining table, a kitchen, and an exit sign.

12. Super 8 by Wyndham Washington

Washington

Gary

CA $129 total

includes taxes & fees

Nov 22 - Nov 23

A hot tub with a rocky backdrop and a mural.

13. Stoney Creek Inn Quincy

Quincy

Kent

CA $157 total

includes taxes & fees

Nov 22 - Nov 23

A spacious living room with a large painting, a fireplace, a staircase, and modern furniture.

14. Best Western Plus Washington Hotel

Washington

Carl

CA $215 total

includes taxes & fees

Nov 11 - Nov 12

A lobby with a reception desk, blue sofas, a coffee table, and a plant display.

15. Drury Inn & Suites St. Louis Arnold

Arnold

Kristine

CA $206 total

includes taxes & fees

Nov 15 - Nov 16

A hotel room with a bed, a lamp, a mirror, and a door.

16. Town & Country Inn and Suites

Quincy

Kelly

CA $201 total

includes taxes & fees

Nov 18 - Nov 19

A modern living area with a sofa, armchairs, a coffee table, and a kitchen in the background.

17. Best Western St. Louis Inn

St. Louis

Susan

CA $110 total

includes taxes & fees

Nov 15 - Nov 16

A hotel room with two beds, a desk, and a window with a view of trees.

18. Best Western Plus Fenton

Fenton

Brian

CA $151 total

includes taxes & fees

Nov 15 - Nov 16

A swimming pool with a metal ladder, surrounded by chairs and large windows offering a view of the sunset.

19. La Quinta Inn & Suites by Wyndham St Louis Route 66

St. Louis

Edward

CA $155 total

includes taxes & fees

Dec 10 - Dec 11

A hotel lobby with a staircase, dining area, and reception desk.

20. Holiday Inn Express & Suites St. Louis West - Fenton by IHG

Fenton

Hollis

CA $152 total

includes taxes & fees

Nov 15 - Nov 16

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Vacation Rentals in Northeast Missouri

Cabin

A park with a pond, picnic tables, and a gazebo.

Cannon Dam Cabins

Perry

"Amazing place to stay! You can’t beat the indoor pool whether it is storming or feels like the fires from hell are raining on earth you can still enjoy a great swim without worrying about lightning or burning to death. The people are incredibly kind and on top of anything you may need and the cabins are a perfect relaxing get away with nice a/c and plenty of sleeping space! Thank you for another amazing stay!"

Cottage

A covered porch with a white door, two folding chairs, and a concrete walkway.

Peaceful Missouri Cabin Rental on 55 Acres!

Canton

"This is a great place to stay if you want to get away from the city. Rural enough to be quiet, but within easy driving distance to a city. Also perfect if you just want to stay on the property and really get away from city life, just bring your groceries. "

Aparthotel

A compact living space with a sofa, a TV, a kitchen area with a fridge, microwave, and coffee maker, and a dining table.

The Mercantile on the Katy Trail

Hermann

"We loved this place- very unique! Clean and great communication from hosts."

Treehouse

A wooden bridge leading to a two-story house with multiple windows and a covered porch.

The Cottage

Hermann

"Our host mentioned he does not receive messages from Expedia postings. So if you are not receiving check-in information, you might want to find another way to contact them. The property is lovely. The Treehouse was perfect for my granddaughter and me."

Apartment

A spacious room with a wooden dining table, chairs, a chandelier, and a bed with white bedding.

Spacious 3-Bedroom with King Bed

Central West End

"Had a great stay! I hosted a birthday dinner for my best friend! Everything was clean and looked great"

Vacation Home

A two-story building with a balcony, outdoor seating area, and string lights.

StayAtlas Retreat w/ Pool, Gym, Games, BBQ

Mount Pleasant

"The property was such a fun surprise- the neighborhood was a little sketchy, but it was great on the inside and the backyard... Great experience, fun complimentary toiletries, etc"

Apartment

A modern hotel lobby with a marble reception desk, a TV mounted on the wall, and a seating area with chairs and a sofa.

Landing Furnished Apartments - Central West End

Central West End

"Parking was behind a large mechanical gate which did not always work. Could sometimes be noisy outside in the evening due to college clientele. Had to park on the street most of the time because of gate issues."

Cottage

Peaceful Missouri Cabin Rental on Large Property

Canton

"The cabin rental was a great stay. Had some connection problems with the t.v. couldn't get past the check out date. The wifi was easy to hook up. The cabin was clean and smelled fresh. Did have some problems with ants on the countertop. Great place to stay, enjoyed our visit."

Apartment

A deck with outdoor furniture, a grill, and a view of a golf course and lake.

Charming Berger Apt on 42-acre Farm w/ Pool Access

Berger

Cottage

A spacious room with a wooden interior, a staircase, a sofa, a table, and a cabinet.

Hillside Cabin on 43 Acres w/ Private Lake & View!

Defiance

"We had a wonderful stay. The property is beautiful and well maintained, and the cabin is cute, comfortable, and well equipped. Nick is a very courteous host. We couldn’t have hoped for a better Thanksgiving getaway!"

Apartment

A red building with a yellow door, a wooden deck, and a chair.

New Melle Apartment Near Missouri Wine Country

Wentzville

"Apartment was wonderful! Very spacious and lots of furniture. Had a flat screen in the living room and bedroom that included Netflix and Prime. Air conditioner worked very well. Was very quiet and in a good location. Property manager was very friendly. There was even a very nice tea selection included with our stay. All amenities including, fridge, sinks, countertop burner, shower, washer, dryer, and toilet worked with no issues. All the dishes and mugs were clean. Plenty of towels to use during...

Apartment

A house with a stone staircase, a balcony, and a garden with pink flowers.

Augusta Studio at Halcyon Spa Bed & Breakfast

Augusta

"Everything was great with this place"

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Stay near popular Northeast Missouri attractions

The Saint Louis Zoo sign with vines on the wall.

St. Louis Zoo

9.2/10 (4,367 reviews)

In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.

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Learn more about Northeast Missouri

Great live music, sports teams, and popular sights from St. Louis Zoo to St. Louis Union Station—explore Northeast Missouri, a family-friendly destination also known for its theaters.

See all hotels in Northeast Missouri

A large eye sculpture in a park surrounded by trees.

Top Northeast Missouri Hotel Reviews

Drury Plaza Hotel St. Louis Union Station

10/10 Excellent

"Excellent location!"

Clayton Plaza Hotel & Extended Stay

8/10 Good

"The hotel was clean for the most part but is obviously old. The shower caulking and flooring had cracks and signs of how dated it is. The rooms were comfortable and the heated pool was nice. The dry sauna worked but is need of serious repair both with the controller and the room itself. The breakfast had plenty of options, though the plastic cutlery made eating some of it difficult."

Sonesta ES Suites St. Louis - Chesterfield

8/10 Good

"My room was aound the back of the building. Im a small woman traveling alone. I was at first put off by the fact that my room was in back of building, it was dark when i arrived. But i said ok i just wanted to lay down. I parked and walked down sidewalk to get to back. There wasa light or 2 with no bulb the walk was not safe feeling thats my main complaint. They need to make sure the pathways are well lit"

Ameristar Casino Resort and Spa

8/10 Good

"We were here for a wedding. Our room was very nice but my son’s bathroom was disgusting and not clean, they had to switch rooms and the only compensation they gave them was a food voucher. Not acceptable with blood and vomit not cleaned from previous guest. We expected more for this caliber of hotel."